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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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N,N,N',N',N'',N''-Hexamethylmethanetriamine → (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester

HRID 30496
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HRID 30496 반응식
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:21])[O:8][C@@:9]([C:14](=[O:20])[N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])([CH2:12][CH3:13])[C:10]=1[CH3:11])=[O:5])[CH3:2].C[C@H]1C[C@@H](OC(=O)C(=O)CC)[C@H](C(C)(C2C=CC=CC=2)C)CC1.[CH3:45][N:46]([CH:48](N(C)C)N(C)C)[CH3:47]>CN(C)C=O>[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:21])[O:8][C@@:9]([C:14](=[O:20])[N:15]([CH2:16][CH3:17])[CH2:18][CH3:19])([CH2:12][CH3:13])[C:10]=1/[CH:11]=[CH:45]/[N:46]([CH3:48])[CH3:47])=[O:5])[CH3:2]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 79831N,N,N',N',N'',N''-HexamethylmethanetriamineHCID 110883962-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl esterHCID 11687992(S)-5-diethylcarbamoyl-5-ethyl-4-methyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester

생성물 1

HCID 11523197(S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

According to the procedure described in Example 6 1.22 0 g of compound (23) as obtained from example 17 (4.103 mmol) in 7.3 mL dimethyl formamide were treated with 7.55 mL tris(dimethylamino)methane (42.26 mmol, 10.3 eq) yielding the crude product as an orange oil (1.463 mg, 101% by weight).

출처 및 근거

ORD 기록
ord-bbd7d798654d40d2a16d1a5d7de0ddf3
출처 데이터셋
uspto-grants-2008_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07423152B2

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