Water → 1-Nitro-4-(2,2,2-trifluoroethoxy)benzene

HRID 3054

반응식

HRID 3054 반응식
[Na].F[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][CH:4]=1.O.[F:13][C:14]([F:18])([F:17])[CH2:15][OH:16]>>[F:13][C:14]([F:18])([F:17])[CH2:15][O:16][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][CH:4]=1

참가 물질

5

반응물 4

HCID 962WaterHCID 64092,2,2-TrifluoroethanolHCID 9590p-FluoronitrobenzeneHCID 5360545Sodium

생성물 1

HCID 27757691-Nitro-4-(2,2,2-trifluoroethoxy)benzene수율 62%

실험 절차

Under a nitrogen atmosphere, 10.1 g (0.44 mol) of sodium was dissolved in 200 ml of 2,2,2-trifluoro ethanol in 300 ml of a three-necked flask, to which 40 ml (0.38 mol) of p-fluoronitro benzene was dropped and refluxed for 4 hours. After cooling to a room temperature, water was poured (about 1 liter), and precipitated solids were washed with water and dried, to obtain p-(2,2,2-trifluoroethoxy) nitrobenzene (yield: 62%; and melting point: 76.5° C.).

후처리

  1. additionwas dropped
  2. temperaturerefluxed for 4 hours
  3. customprecipitated solids
  4. washwere washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-174ccccc38a64a6887d340e17eeb43b4
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733481

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