Potassium Carbonate → 3-(N,N-diethylaminopropoxy)butyranilide

HRID 30543

반응식

HRID 30543 반응식
S([O-])(=O)(=O)C.[CH2:6]([N:8]([CH:11](O)[CH2:12][CH3:13])[CH2:9][CH3:10])[CH3:7].[C:15]([NH:20][C:21]1[CH:22]=[C:23](O)[CH:24]=[CH:25][CH:26]=1)(=[O:19])[CH2:16][CH2:17][CH3:18].C([O-])([O-])=[O:29].[K+].[K+]>CN(C=O)C>[CH2:6]([N:8]([CH2:11][CH2:12][CH2:13][O:29][CH:17]([CH3:18])[CH2:16][C:15]([NH:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:19])[CH2:9][CH3:10])[CH3:7]

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 30688Butyranilide, 3'-hydroxy-HCID 85257MethanesulfonateHCID 5256659Diethylamino-propanol

생성물 1

HCID 684282403-(N,N-diethylaminopropoxy)butyranilide수율 88.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The mesylate of N,N-diethylaminopropanol (6 mmol), prepared as described in Example 18 above, was mixed with 3-butyramidophenol (5.0 mmol), and K2CO3 (10 mmol) in anhydrous DMF (10 mL) and the reaction is performed following general procedure B. The crude product is purified using silica gel column chromatography 5% MeOH/DCM as eluent to yield 3-(N,N-diethylaminopropoxy)butyranilide (1.3 g).

후처리

  1. customThe crude product is purified

출처 및 근거

ORD 기록
ord-67fb278fb8d946049d25207848a9308e
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423177B2

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