1-Bromo-2-iodobenzene → 2'-Bromo-4-(2-dimethylamino-ethoxy)-biphenyl-3-carbaldehyde

반응식

[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9](B(O)O)=[CH:8][C:7]=1[CH:15]=[O:16].[Br:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1I>>[Br:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][N:2]([CH3:17])[CH3:1])=[C:7]([CH:15]=[O:16])[CH:8]=1

참가 물질

반응물 2

HCID 114151-Bromo-2-iodobenzene

HCID 858888554-(2-Dimethylamino-ethoxy)-3-formyl-benzeneboronic acid

생성물 1

HCID 866010072'-Bromo-4-(2-dimethylamino-ethoxy)-biphenyl-3-carbaldehyde수율 68%

실험 절차

General procedure G, using 4-(2-dimethylamino-ethoxy)-3-formyl-benzeneboronic acid and 1-bromo-2-iodo-benzene gave the title product as yellow oil in 68% yield. 1H-NMR (CDCl3) δ 10.51 (s, 1H), 7.90 (d, 1H), 7.70-7.65 (m, 2H), 7.41-7.20 (m, 3H), 7.09 (d, 1H), 4.40 (t, 2H), 3.04 (bs, 2H), 2.56 (s, 6H).

출처 및 근거

ORD 기록: ord-808575f3ad864d1ca959865a121f6924
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07423181B2

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