4-Nitrobenzaldehyde → 5-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione

HRID 30642

반응식

HRID 30642 반응식
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[S:12]1[CH2:16][C:15](=[O:17])[NH:14][C:13]1=[O:18].N1CCCCC1>C(O)C>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[C:16]2[S:12][C:13](=[O:18])[NH:14][C:15]2=[O:17])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 5414-NitrobenzaldehydeHCID 5437ThiazolidinedioneHCID 8082Piperidine

생성물 1

HCID 27682645-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione수율 59.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-nitrobenzaldehyde (15.1 g), 1,3-thiazolidine-2,4-dione (11.70 g), piperidine (1.70 g) and ethanol (300 mL) was heated under reflux for 24 hrs. The reaction mixture was concentrated. The obtained residue was washed with ethanol to give 5-(4-nitrobenzylidene)-1,3-thiazolidine-2,4-dione as yellow crystals (14.8 g, yield 59%). Recrystallization thereof from acetone-hexane gave pale-yellow prism crystals. melting point: 272-273° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 24 hrs
  3. concentrationThe reaction mixture was concentrated
  4. washThe obtained residue was washed with ethanol

출처 및 근거

ORD 기록
ord-02854ddf1583494d8386c11c20c29345
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423159B2

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