Tetrahydrofuran → Methyl 4-hydroxy-2-methoxybenzoate

HRID 30740

반응식

HRID 30740 반응식
C([O:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:11]([O:19][CH3:20])[CH:10]=1)C1C=CC=CC=1.O1CCCC1>CO.[C].[Pd]>[OH:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:11]([O:19][CH3:20])[CH:10]=1

참가 물질

5

반응물 2

HCID 8028TetrahydrofuranHCID 108260394-Benzyloxy-2-methoxybenzoic acid methyl ester

생성물 1

HCID 12532676Methyl 4-hydroxy-2-methoxybenzoate수율 98%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

To a solution of methyl 4-benzyloxy-2-methoxybenzoate (3.08 g) in methanol (5 mL)/tetrahydrofuran (7.5 mL) was added 10% palladium-carbon (0.3 g) at room temperature under an atmosphere of argon, and the mixture was stirred at that temperature for 2 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to afford the title compound (2.02 g).

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-cac98ee240c347b09e50e6d4c18e0653
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423185B2

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