[CH2:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:11][CH:10]=1)=[O:7])[CH:2]([CH3:4])[CH3:3].C(N(CC)CC)C.CN(C)C(=O)C.[C:32](Cl)(=[O:36])[C:33]([CH3:35])=[CH2:34]>O>[CH2:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([NH:18][C:32](=[O:36])[C:33]([CH3:35])=[CH2:34])(=[O:16])=[O:17])=[CH:11][CH:10]=1)=[O:7])[CH:2]([CH3:4])[CH3:3]To a mixture of 54.4 g of p-isobutyloxycarbonylaminophenyl sulfonamide, 40 g of triethylamine, 2 g of N,N-dimethylaminopyridine and 150 ml of N,N-dimethylacetamide was then added dropwise 22.8 g of methacrylic chloride under cooling with ice. After the completion of the dropwise addition, the reaction mixture was stirred for 2 hours. The reaction product was then poured into water. The resulting crystal was then withdrawn by filtration. The crystal was then recrystallized from a 3/7 (by volume) mixture of toluene and ethyl acetate to obtain 40 g of N-(p-isobutyloxycarbonylaminophenylsulfonyl)methacrylamide in the form of white crystal (m.p. 194°-196° C.).
불러오는 중…
