Thiophosgene → HCID 178440816, 화합물

HRID 30794

반응식

HRID 30794 반응식
[C:1]([C:5]1[CH:6]=[C:7]([NH2:11])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)(O)[O-].[Na+].C(Cl)(Cl)=[S:18]>CC(C)=O>[N-:11]=[C:7]=[S:18].[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 10040ThiophosgeneHCID 793343-tert-ButylanilineHCID 516892Sodium Bicarbonate

생성물 1

HCID 178440816HCID 178440816, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To 3-(tert-butyl)phenylamine in acetone at 0° C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq). The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water. The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 3-(tert-butyl)benzenisothiocyanate. MS: MH+=192.

후처리

  1. customwas brought to ambient temperature
  2. concentrationconcentrated
  3. custompartitioned between ethyl acetate and water
  4. dry with materialThe organic layer was dried with sodium bicarbonate and sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5c2f9b6dcb724652b0a751510608c005
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423150B2

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