Malononitrile → (2-Fluorobenzylidene)malononitrile
반응식
[C:1](#[N:5])[CH2:2][C:3]#[N:4].[F:6][C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[CH:9]=O.N1CCCCC1>C(OC(C)C)(=O)C>[F:6][C:7]1[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=1[CH:9]=[C:2]([C:1]#[N:5])[C:3]#[N:4]참가 물질
5
실험 절차
Malononitrile (3.303 g, 50 mmol), 2-fluorobenzaldehyde (6.205 g, 50 mmol), 1 g of molecular sieves, and 500 mg of a resin bound piperidine (described in Tetrahedron Lett., 1999, 40, 7031-33) were placed in a vessel which was irradiated in a 300 W single mode microwave for 15 seconds. The reaction mixture was taken up in iso-propyl acetate, filtered, evaporated, taken up in dichloromethane, filtered through a pad of Magnasol, evaporated, and recrystallized from ethanol to yield 2.435 g of the title material as a crystalline solid,
후처리
- customwere placed in a vessel
- customwhich was irradiated in a 300 W single mode microwave for 15 seconds
- filtrationfiltered
- customevaporated
- filtrationfiltered through a pad of Magnasol
- customevaporated
- customrecrystallized from ethanol
출처 및 근거
- ORD 기록
- ord-8e87faf475de4826847a48546c5fff7a
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07425580B2
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