Sodium Hydroxide → 4-(2-Phenyl-cyclopropylcarbamoyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester
반응식
C[O:2][C:3]([CH:5]1[CH2:9][CH:8]([C:10](=[O:21])[NH:11][CH:12]2[CH2:14][CH:13]2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:7][N:6]1[C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])=[O:4].[OH-].[Na+]>C1COCC1>[CH2:25]([O:24][C:22]([N:6]1[CH2:7][CH:8]([C:10](=[O:21])[NH:11][CH:12]2[CH2:14][CH:13]2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:9][CH:5]1[C:3]([OH:4])=[O:2])=[O:23])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1참가 물질
4
실험 절차
To a solution of 4-(2-Phenyl-cyclopropylcarbamoyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (422 mg, 1 mmol) in THF (2 mL) was added 1 N NaOH (1.5 mL) at 0° C. with stirring. After 30 min at 0° C. and 16 h at room temperature, the reaction mixture was concentrated and treated with EtOAc and 6 N HCl (5 mL). The organic layer was dried over MgSO4 and concentrated. The residue was purified by a silica gel column using CH2Cl2/MeOH (95:5) as eluant to yield the desired compound as a colorless oil (343 mg, 84%).