Thionyl Chloride → 3-Iodo-4-methylbenzoyl chloride

HRID 31399

반응식

HRID 31399 반응식
S(Cl)([Cl:3])=O.[I:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9](O)=[O:10]>C(Cl)(Cl)Cl>[I:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9]([Cl:3])=[O:10]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 6216403-Iodo-4-methylbenzoic acid

생성물 1

HCID 177521573-Iodo-4-methylbenzoyl chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
61 °C

실험 절차

Thionyl chloride (8.2 ml, 112.5 mmol) was added to a mixture of 3-iodo-4-methylbenzoic acid (18.5 g, 75 mmol) in chloroform (100 ml) and heated at 61° C. for 16 hours. The solvent was removed in vacuo and excess thionyl chloride removed by azeotroping with toluene (3×30 ml). The desired product was formed as a beige solid (19.5 g 93%) and used in subsequent reactions without further purification.

후처리

  1. customThe solvent was removed in vacuo and excess thionyl chloride
  2. customremoved
  3. customby azeotroping with toluene (3×30 ml)

출처 및 근거

ORD 기록
ord-f706d26ebb73471d909c51f1695ddd4a
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425555B2

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