Morpholine → 4-(3-Nitrophenyl)morpholine

HRID 31400

반응식

HRID 31400 반응식
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CS(C)=O>[N+:8]([C:4]1[CH:3]=[C:2]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][CH:5]=1)([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 98231-Fluoro-3-nitrobenzene

생성물 1

HCID 12532734-(3-Nitrophenyl)morpholine

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
110 °C

실험 절차

3-Fluoronitrobenzene (10 g, 71 mmol) was added to a solution of morpholine (34 ml, 390 mmol) in dimethylsulfoxide (120 ml) and heated at 110° C. for 60 hours. The reaction was cooled and poured onto water (800 ml). The desired product precipitated and was collected by filtration. The orange solid was dried in vacuo and used in subsequent reactions without further purification (13.7 g, 66 mmol).

후처리

  1. temperatureThe reaction was cooled
  2. additionpoured onto water (800 ml)
  3. customThe desired product precipitated
  4. filtrationwas collected by filtration
  5. customThe orange solid was dried in vacuo
  6. customused in subsequent reactions without further purification (13.7 g, 66 mmol)

출처 및 근거

ORD 기록
ord-37b9b77e1244444086434082d264cf48
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425555B2

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