Morpholine → 4-(3-Nitrophenyl)morpholine
반응식
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CS(C)=O>[N+:8]([C:4]1[CH:3]=[C:2]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][CH:5]=1)([O-:10])=[O:9]참가 물질
4
반응 조건
- 온도
- 110 °C
실험 절차
3-Fluoronitrobenzene (10 g, 71 mmol) was added to a solution of morpholine (34 ml, 390 mmol) in dimethylsulfoxide (120 ml) and heated at 110° C. for 60 hours. The reaction was cooled and poured onto water (800 ml). The desired product precipitated and was collected by filtration. The orange solid was dried in vacuo and used in subsequent reactions without further purification (13.7 g, 66 mmol).
후처리
- temperatureThe reaction was cooled
- additionpoured onto water (800 ml)
- customThe desired product precipitated
- filtrationwas collected by filtration
- customThe orange solid was dried in vacuo
- customused in subsequent reactions without further purification (13.7 g, 66 mmol)
출처 및 근거
- ORD 기록
- ord-37b9b77e1244444086434082d264cf48
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07425555B2
반응 노트
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