1-Bromo-2-Chloroethane → 1-(3-Bromophenyl)cyclopropane-1-carbonitrile

HRID 31497

반응식

HRID 31497 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[CH2:5][C:6]#[N:7].Br[CH2:12][CH2:13]Cl.[OH-].[Na+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.O>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2([C:6]#[N:7])[CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1

참가 물질

6

반응물 3

HCID 78491-Bromo-2-ChloroethaneHCID 14798Sodium HydroxideHCID 36023(3-Bromophenyl)acetonitrile

생성물 1

HCID 200261781-(3-Bromophenyl)cyclopropane-1-carbonitrile

시약·촉매·용매 2

HCID 66133Benzyl triethylammonium chloride촉매HCID 962Water용매

실험 절차

25 g (0.13 mol) of 3-bromo-benzylcyanide are taken up in 32 ml (0.38 mol) of 1-bromo-2-chloro-ethane and combined with 0.6 g (2.6 mmol) of benzyltriethylammonium chloride. Then a solution of 105.8 g (2.65 mol) of sodium hydroxide in 106 ml of water is added dropwise at 10 to 25° C. After 20 hours at 55° C. the reaction solution is poured onto ice water and extracted with ethyl acetate. The organic extracts are dried and evaporated down. The residue is triturated with petroleum ether, suction filtered and dried.

후처리

  1. additionAfter 20 hours at 55° C. the reaction solution is poured onto ice water
  2. extractionextracted with ethyl acetate
  3. customThe organic extracts are dried
  4. customevaporated down
  5. customThe residue is triturated with petroleum ether, suction
  6. filtrationfiltered
  7. customdried

출처 및 근거

ORD 기록
ord-b3bcfc84b2f1474e97d064fd72e6f4ff
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425641B2

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