Benzoyl chloride → 3-cyano-N-[4-(benzoylamino)-benzyl]-benzamide

HRID 31499노트

반응식

HRID 31499 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([C:12]1[CH:13]=[C:14]([CH:26]=[CH:27][CH:28]=1)[C:15]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)=[O:16])#[N:11].C(N(CC)CC)C>C(Cl)Cl>[C:10]([C:12]1[CH:13]=[C:14]([CH:26]=[CH:27][CH:28]=1)[C:15]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:21][CH:20]=1)=[O:16])#[N:11]

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 608931683-cyano-N-(4-amino-benzyl)-benzamide

생성물 1

HCID 693086213-cyano-N-[4-(benzoylamino)-benzyl]-benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 0.6 g (4.2 mmol) of benzoylchloride in 10 ml of methylene chloride is added dropwise to a solution of 1 g (4 mmol) of 3-cyano-N-(4-amino-benzyl)-benzamide and 0.6 g (6 mmol) of triethylamine in 30 ml of methylene chloride at ambient temperature. After 8 hours at ambient temperature the product which has crystallised out is dissolved in methylene chloride and methanol. After extraction with water the combined organic extracts are dried and evaporated down.

후처리

  1. customAfter 8 hours at ambient temperature the product which has crystallised out
  2. dissolutionis dissolved in methylene chloride
  3. extractionAfter extraction with water the combined organic extracts
  4. customare dried
  5. customevaporated down

출처 및 근거

ORD 기록
ord-2bed51339cdf4881b929757cb7991d35
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425641B2

반응 노트

불러오는 중…