Imidazole → N,N-Dimethyl-1H-imidazole-1-sulfonamide

HRID 31542

반응식

HRID 31542 반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.C(N(CC)CC)C.[CH3:13][N:14]([CH3:19])[S:15](Cl)(=[O:17])=[O:16]>C1(C)C=CC=CC=1>[CH3:13][N:14]([CH3:19])[S:15]([N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)(=[O:17])=[O:16]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 8471TriethylamineHCID 83372Dimethylsulphamoyl chloride

생성물 1

HCID 395751N,N-Dimethyl-1H-imidazole-1-sulfonamide수율 98.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Imidazole (5.00 g, 73.6 mmol) was dissolved in toluene (80 ml), and thereto were added triethylamine (9.52 ml, 68.4 mmol) and dimethylsulfamoyl chloride (6.77 ml, 63.3 mmol), and the mixture was stirred at room temperature for 8 hours. The precipitates were removed by filtration, and the filtrate was concentrated under reduced pressure. The resulting residue was subjected to azeotropic distillation with hexane to give the title compound (10.9 g, 98%).

후처리

  1. customThe precipitates were removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. distillationThe resulting residue was subjected to azeotropic distillation with hexane

출처 및 근거

ORD 기록
ord-cdd939ed61584f64924ac03c476e701c
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425642B2

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