Dimethylformamide → 2-Oxobutyl benzoate

HRID 31659

반응식

HRID 31659 반응식
Br[CH2:2][C:3](=[O:6])[CH2:4][CH3:5].[C:7]([O-:15])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[Na+].CN(C)C=O>C(OCC)C>[C:7]([O:15][CH2:2][C:3](=[O:6])[CH2:4][CH3:5])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 131561-Bromo-2-butanoneHCID 517055Sodium Benzoate

생성물 1

HCID 157432722-Oxobutyl benzoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 1-bromobutan-2-one (7.2 g, 47.7 mmol), sodium benzoate (7.56 g, 52.4 mmol), and N,N-dimethylformamide (72 ml) was stirred at room temperature for 3 hours and 45 minutes. Diethyl ether was added to the reaction mixture and the mixture was washed with water and a saturated saline solution, dried over magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure to obtain the title compound (9.5 g, quantitatively) as a light brown oil.

후처리

  1. washthe mixture was washed with water
  2. dry with materiala saturated saline solution, dried over magnesium sulfate
  3. filtrationfiltrated
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7d7c0015b0cc406bb4bdac4994bc8c15
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425634B2

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