Solketal → HCID 178431368, 화합물

HRID 31680

반응식

[Na:1].[CH3:2][C:3]1([CH3:31])[O:8]C[CH:6]([CH2:9][O:10][C:11]2[C:16](C)=[CH:15][N:14]=[C:13]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:12]=2[CH3:30])[CH2:5][O:4]1.CC1(C)OC(CO)CO1.ClC1C=C[N+]([O-])=C(C)C=1C.[F:51]C1C=CC2NC(S)=NC=2C=1>>[Na:1].[CH3:2][C:3]1([CH3:31])[O:8][CH:6]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][C:28]([F:51])=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:12]=2[CH3:30])[CH2:5][O:4]1

참가 물질

반응물 4

HCID 7528Solketal

HCID 98774464-Chloro-2,3-dimethyl-1-oxidopyridin-1-ium

HCID 667758472-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HCID 178505474HCID 178505474, 화합물

생성물 1

HCID 178431368HCID 178431368, 화합물수율 14.1%

실험 절차

The same procedure as in the step (10b) of Example 10 and the step (14b) of Example 14, the step (5f) of Example 5, the steps (11h) and (11i) of Example 11 was repeated using solketal, 4-chloro-2,3-dimethylpyridine 1-oxide, and 5-fluoro-1H-benzimidazole-2-thiol to obtain the title compound (210 mg, yield: 14.1%) as a white solid. Note that methanol was used as a solvent instead of ethanol in the same operation as in the step (5f).

출처 및 근거

ORD 기록: ord-a11e91989b544cc486de35037d86b48b
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07425634B2

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