4-Chloro-2,3,5-trimethyl-1-oxidopyridin-1-ium → 2-(((4-(1,4-Dioxan-2-ylmethoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31683

반응식

HRID 31683 반응식
[Na:1].[O:2]1[CH2:7][CH2:6][O:5][CH2:4][CH:3]1[CH2:8][O:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][S:17]([C:19]2[NH:23][C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[N:20]=2)=[O:18])[C:11]=1[CH3:28].Cl[C:30]1C(C)=C[N+]([O-])=C(C)C=1C>>[Na:1].[O:2]1[CH2:7][CH2:6][O:5][CH2:4][CH:3]1[CH2:8][O:9][C:10]1[C:15]([CH3:30])=[CH:14][N:13]=[C:12]([CH2:16][S:17]([C:19]2[NH:20][C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=3[N:23]=2)=[O:18])[C:11]=1[CH3:28]

참가 물질

3

반응물 2

HCID 27791414-Chloro-2,3,5-trimethyl-1-oxidopyridin-1-iumHCID 66776308HCID 66776308, 화합물

생성물 1

HCID 667762422-(((4-(1,4-Dioxan-2-ylmethoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt수율 18%

실험 절차

The same procedure as in the steps (62a) to (62d) of Example 62 was repeated using 4-chloro-2,3,5-trimethylpyridine 1-oxide to obtain the title compound (355 mg, total yield: 18%) as a white solid.

출처 및 근거

ORD 기록
ord-b5a50899ee1e4c739ff3100981252503
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425634B2

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