2-Chloro-5-(trifluoromethyl)pyridine → {4-[4-Fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}(2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine

HRID 31891

반응식

HRID 31891 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.Cl[C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][N:17]=1.ClC1C=C(Cl)C=CC=1C1[C:39]([C:40]2[NH:41][CH:42]=[CH:43][N:44]=2)=[CH:38][N:37]=[C:36]([NH:45][CH2:46][CH2:47][NH:48]C2C=CC([N+]([O-])=O)=CN=2)[N:35]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[C:39]([C:40]3[NH:41][CH:42]=[CH:43][N:44]=3)=[CH:38][N:37]=[C:36]([NH:45][CH2:46][CH2:47][NH:48][C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][N:17]=3)[N:35]=2)=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1

참가 물질

4

반응물 3

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 6056804-Fluoro-2-(trifluoromethyl)benzoyl chlorideHCID 9847557Chir-98023

생성물 1

HCID 22142758{4-[4-Fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}(2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine

실험 절차

{4-[4-fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}(2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine was prepared from 4-fluoro-2-(trifluoromethyl)benzoyl chloride and 2-chloro-5-(trifluoromethyl)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

출처 및 근거

ORD 기록
ord-5ba8b4976bb840ecae19d4a9ed2ef649
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425557B2

연결된 노트

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