2-Chloro-5-(trifluoromethyl)pyridine → {4-[4-Fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}(2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine
반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.Cl[C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][N:17]=1.ClC1C=C(Cl)C=CC=1C1[C:39]([C:40]2[NH:41][CH:42]=[CH:43][N:44]=2)=[CH:38][N:37]=[C:36]([NH:45][CH2:46][CH2:47][NH:48]C2C=CC([N+]([O-])=O)=CN=2)[N:35]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[C:39]([C:40]3[NH:41][CH:42]=[CH:43][N:44]=3)=[CH:38][N:37]=[C:36]([NH:45][CH2:46][CH2:47][NH:48][C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][N:17]=3)[N:35]=2)=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1참가 물질
4
실험 절차
{4-[4-fluoro-2-(trifluoromethyl)phenyl]-5-imidazol-2-ylpyrimidin-2-yl}(2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine was prepared from 4-fluoro-2-(trifluoromethyl)benzoyl chloride and 2-chloro-5-(trifluoromethyl)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.