Sodium Hydroxide → 5-Cyano-2-iodobenzoic acid

HRID 321998노트

반응식

HRID 321998 반응식
[OH-].[Na+].C[O:4][C:5](=[O:15])[C:6]1[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=1[I:14]>O.CO>[I:14][C:7]1[CH:8]=[CH:9][C:10]([C:12]#[N:13])=[CH:11][C:6]=1[C:5]([OH:15])=[O:4]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 23076822Methyl 5-cyano-2-iodobenzoate

생성물 1

HCID 220088225-Cyano-2-iodobenzoic acid수율 66.2%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of sodium hydroxide (0.44 g, 11 mmol) in water (10 ml) was added to 2-iodo-5-cyanobenzoic acid methyl ester (2.7 g, 9.4 mmol) in methanol. The mixture was stirred for 20 h, then most of the solvent was evaporated and the residue acidified with 2N hydrochloric acid. The resulting precipitate was filtered off and dried to give a white solid (1.7 g). MS (−CI) m/z 272 [M-H]+.

후처리

  1. custommost of the solvent was evaporated
  2. filtrationThe resulting precipitate was filtered off
  3. customdried

출처 및 근거

ORD 기록
ord-d0e0c6c8931248808b8d7128df7ffa4f
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211189B1

반응 노트

불러오는 중…