Toluene → 2-Benzyloxy-6-bromopyridine

HRID 322063

반응식

HRID 322063 반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[OH-:9].[K+].[C:11]1([CH3:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1OCCOCCOCCOCCOCCOC1>[CH2:17]([O:9][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 122742,6-DibromopyridineHCID 14797Potassium Hydroxide

생성물 1

HCID 8174752-Benzyloxy-6-bromopyridine

시약·촉매·용매 1

HCID 2855718-Crown-6촉매

실험 절차

A stirred mixture of 2,6-dibromopyridine (3.55 g), benzyl. alcohol (1.63 g), potassium hydroxide (1.68 g), 18-Crown-6 (0.20 g) and toluene (25 ml) is heated under reflux for 30 minutes. The cool solution washed with water and brine, dried (MgSO4) and evaporated to give an oil which is vacuum-distilled (Kugelrohr) to give 3.85 g of 2-benzyloxy-6-bromopyridine, bp 220-225° C./1.0 mm.

후처리

  1. temperatureunder reflux for 30 minutes
  2. washThe cool solution washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. customto give an oil which
  6. distillationis vacuum-distilled (Kugelrohr)

출처 및 근거

ORD 기록
ord-93682894d27b42bb9ad767ec95113533
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211220B1

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