Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → 2-Benzyloxy-6-bromopyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 2,6-Dibromopyridine | HCID 12274 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 촉매 | 18-Crown-6 | HCID 28557 | — |
| 생성물 | 2-Benzyloxy-6-bromopyridine | HCID 817475 | — |
반응 단계
A stirred mixture of 2,6-dibromopyridine (3.55 g), benzyl. alcohol (1.63 g), potassium hydroxide (1.68 g), 18-Crown-6 (0.20 g) and toluene (25 ml) is heated under reflux for 30 minutes. The cool solution washed with water and brine, dried (MgSO4) and evaporated to give an oil which is vacuum-distilled (Kugelrohr) to give 3.85 g of 2-benzyloxy-6-bromopyridine, bp 220-225° C./1.0 mm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211220B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-93682894d27b42bb9ad767ec95113533 |
| 출처 메모 | uspto-grants-2001_04 |