Hydrochloric Acid → HCID 22010045, 화합물

HRID 322233노트

반응식

HRID 322233 반응식
Cl.C([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][O:14][C:13]3[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:12]=3[C:11](=[O:22])[C:10]=2[CH:23]=1)(=O)C>CO>[NH2:5][C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][O:14][C:13]3[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:12]=3[C:11](=[O:22])[C:10]=2[CH:23]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22010021HCID 22010021, 화합물

생성물 1

HCID 22010045HCID 22010045, 화합물수율 74%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a mixed solvent of concentrated hydrochloric acid (15 ml) and methanol (15 ml), 9-acetamido-2-methoxy-6,11-dihydrodibenz[b,e]oxepin-11-one obtained in Reference Example 10 (0.93 g, 3.1 mmol) was heated under reflux for one hour. After the reaction was completed, substantially the same procedure as in Reference Example 5 was repeated to give 9-amino-2-methoxy-6,11-dihydrodibenz[b,e]oxepin-11-one (yield: 74%).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for one hour

출처 및 근거

ORD 기록
ord-8bdb4437101347009b2143c431181bed
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211227B1

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