1,3-Dichloroacetone → 4-(Chloromethyl)-2-(3,4-dihydronaphthalen-2-yl)oxazole

반응식

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[C:11]([NH2:13])=[O:12].[Cl:14][CH2:15][C:16]([CH2:18]Cl)=O>>[Cl:14][CH2:15][C:16]1[N:13]=[C:11]([C:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)[O:12][CH:18]=1

참가 물질

반응물 2

HCID 107931,3-Dichloroacetone

HCID 220098193,4-Dihydro-2-naphthalenecarboxamide

생성물 1

HCID 220096374-(Chloromethyl)-2-(3,4-dihydronaphthalen-2-yl)oxazole수율 60%

실험 절차

In substantially the same manner as in Reference Example 31, 3,4-dihydro-2-naphthalenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3,4-dihydro-2-naphthyl)oxazole. The yield was 60%. Recrystallization from isopropyl ether gave colorless prisms, mp 73-74° C.

출처 및 근거

ORD 기록: ord-925a11c0d6e349ac82ecc515deccfd8e
출처 데이터셋: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06211215B1

반응 노트

불러오는 중…