1,3-Dichloroacetone → 4-(Chloromethyl)-2-(propan-2-yl)-1,3-oxazole

반응식

[C:1]([NH2:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[Cl:7][CH2:8][C:9]([CH2:11]Cl)=O>>[Cl:7][CH2:8][C:9]1[N:6]=[C:1]([CH:2]([CH3:4])[CH3:3])[O:5][CH:11]=1

참가 물질

반응물 2

HCID 107931,3-Dichloroacetone

HCID 68424Isobutyramide

생성물 1

HCID 27632914-(Chloromethyl)-2-(propan-2-yl)-1,3-oxazole수율 6.2%

실험 절차

In substantially the same manner as in Reference Example 31, isobutyramide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-isopropyl oxazole as an oily product. The yield was 6.2%.

출처 및 근거

ORD 기록: ord-08f66c51c9c04a2db715dc2ff5cdaa9f
출처 데이터셋: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06211215B1

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