1,3-Dichloroacetone → 4-Chloromethyl-2-(3,5-dimethoxyphenyl)oxazole
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:12][CH3:13])[CH:11]=1)[C:6]([NH2:8])=[O:7].[Cl:14][CH2:15][C:16]([CH2:18]Cl)=O>>[Cl:14][CH2:15][C:16]1[N:8]=[C:6]([C:5]2[CH:9]=[C:10]([O:12][CH3:13])[CH:11]=[C:3]([O:2][CH3:1])[CH:4]=2)[O:7][CH:18]=1참가 물질
3
실험 절차
In substantially the same manner as in Reference Example 31, 3,5-dimethoxybenzamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3,5-dimethoxyphenyl)oxazole. The yield was 59%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 85-86° C.
출처 및 근거
- ORD 기록
- ord-1e068f773ee24b4ebacd0233d74729f9
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06211215B1
반응 노트
불러오는 중…