1,3-Dichloroacetone → HCID 11806574, 화합물

반응식

[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]([NH2:12])=[O:11].[Cl:13][CH2:14][C:15]([CH2:17]Cl)=O>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[O:11][CH:17]=[C:15]([CH2:14][Cl:13])[N:12]=1

참가 물질

반응물 2

HCID 107931,3-Dichloroacetone

HCID 6871212-Benzofurancarboxamide

생성물 1

HCID 11806574HCID 11806574, 화합물수율 30%

실험 절차

In substantially the same manner as in Reference Example 47, 2-benzofurancarboxamide was allowed to react with 1,3-dichloroacetone to give 2-(2-benzofuranyl)-4-chloromethyloxazole. The yield was 30%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 133-134° C.

출처 및 근거

ORD 기록: ord-f99bc33560fb4c478d86678dbb3b3433
출처 데이터셋: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06211215B1

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