1,3-Dichloroacetone → 4-Chloromethyl-2-(5-cyano-2-thienyl)oxazole
반응식
[C:1]([C:3]1[S:7][C:6]([C:8]([NH2:10])=[O:9])=[CH:5][CH:4]=1)#[N:2].[Cl:11][CH2:12][C:13]([CH2:15]Cl)=O>>[Cl:11][CH2:12][C:13]1[N:10]=[C:8]([C:6]2[S:7][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[O:9][CH:15]=1참가 물질
3
실험 절차
In substantially the same manner as in Reference Example 47, 5-cyano-2-thiophenecarboxamide was reacted with 1,3-dichloroacetone to obtain 4-chloromethyl-2-(5-cyano-2-thienyl)oxazole. The yield was 22%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 146-147° C.
출처 및 근거
- ORD 기록
- ord-24fec3037f8f47a7810991f9bbb98d4c
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06211215B1
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