6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine → 6-Bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine

HRID 322440

반응식

HRID 322440 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)=[CH:4][CH:3]=1.[Br:16][C:17]1[CH:18]=[CH:19][C:20]2[N:21]([CH:23]=[C:24]([CH2:26]Cl)[N:25]=2)[CH:22]=1>>[Br:16][C:17]1[CH:18]=[CH:19][C:20]2[N:21]([CH:23]=[C:24]([CH2:26][O:1][C:2]3[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)=[CH:4][CH:3]=3)[N:25]=2)[CH:22]=1

참가 물질

3

반응물 2

HCID 116228946-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridineHCID 220098181-[3-(4-Hydroxyphenyl)propyl]imidazole

생성물 1

HCID 220098516-Bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine수율 57%

실험 절차

In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 6-bromo-2-chloromethylimidazo[1,2-a]pyridine to give 6-bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine. The yield was 57%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 103-104° C.

출처 및 근거

ORD 기록
ord-d7bb8b1d28d846d68bd82fd358c0148f
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211215B1

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