4-Methylmorpholine → Ethyl acetate ethanol ammonia

HRID 322498노트

반응식

HRID 322498 반응식
[O:1]=[C:2]1[CH:7](CCC2C=CC3CCCNC=3N=2)CCC[N:3]1[CH2:20][C:21]([OH:23])=[O:22].CN1CCO[CH2:27][CH2:26]1.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1>CC#N>[NH3:3].[CH3:7][CH2:2][OH:1].[CH3:26][CH2:27][O:23][C:21]([CH3:20])=[O:22]

참가 물질

5

반응물 3

HCID 79724-MethylmorpholineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 22008800HCID 22008800, 화합물

생성물 1

HCID 86587043Ethyl acetate ethanol ammonia

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A stirred mixture of 1-8 (71 mg, 0.20 mmol), 1-9 (59 mg, 0.22 mmol) (Rico et al., J. Org. Chem., 1993, 58, 7948), NMM (88 μL, 0.8 mmol), and CH3CN (25 mL) was treated with BOP (97 mg, 0.22 mmol). After 24 h, the reaction mixture was concentrated to dryness, dissolved in EtOAc, and then washed with H2O, dried (MgSO4), and concentrated. Flash chromatography (silica, 10% (NH3/EtOH/EtOAc) gave 1-10 as a colorless gum.

후처리

  1. concentrationthe reaction mixture was concentrated to dryness
  2. dissolutiondissolved in EtOAc
  3. washwashed with H2O
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6ed823079f2249778c51d799d559c2c1
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211184B1

반응 노트

불러오는 중…