2-Acetylnaphthalene → N-[1-(2-naphthyl)ethyl]-1-(3-methoxyphenyl)ethylamine

HRID 322597

반응식

HRID 322597 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]([NH2:11])[CH3:10])[CH:6]=[CH:7][CH:8]=1.[C:12]([C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=1)(=O)[CH3:13]>CC(C)[O-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-]>[CH:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:23]=[CH:24][C:15]=1[CH:12]([NH:11][CH:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=1)[CH3:10])[CH3:13]

참가 물질

4

반응물 2

HCID 71222-AcetylnaphthaleneHCID 46120581-(3-Methoxyphenyl)ethanamine

생성물 1

HCID 22011059N-[1-(2-naphthyl)ethyl]-1-(3-methoxyphenyl)ethylamine

시약·촉매·용매 1

HCID 11026Titanium isopropoxide촉매

실험 절차

In a similar fashion equal molar amounts 1-(3-methoxyphenyl)ethylamine (1.51 g, 10 mmol), 2′-acetonaphthone (1.70 g, 10 mmol) and 1.25 equivalents of titanium(IV) isopropoxide (3.55 g, 12.5 mmol) were treated as above. Work-up yielded N-[1-(2-naphthyl)ethyl]-1-(3-methoxyphenyl)ethylamine, 6F, as a clear, colorless oil; m/z (rel. int.) 305 (M+, 1), 290 (35), 170 (49), 155 (100), 135 (55), 115 (8), 105 (10), 91 (9), 77 (10).

출처 및 근거

ORD 기록
ord-4464b040a8584a058b6e9f2f05b92b04
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211244B1

연결된 노트

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