Thionyl Chloride → 1-(2-Chloroethoxy)-4-nitrobenzene

반응식

[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12]O)=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)([Cl:16])=O>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][Cl:16])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 853812-(4-Nitrophenoxy)ethanol

생성물 1

HCID 27645871-(2-Chloroethoxy)-4-nitrobenzene

실험 절차

4-Nitro-(2-Hydroxyethoxy)benzene (1.13 g, 6.2 mmol) in thionyl chloride (10 mL) is heated at reflux for 3 hours then concentrated in vacuo. After cooling the residue in an ice water bath, saturated aqueous sodium bicarbonate is added and the precipitate collected, rinsed with water, and dried to give 4-nitro-(2-chloroethoxy)benzene (909 mg).

후처리

temperatureat reflux for 3 hours
concentrationthen concentrated in vacuo
temperatureAfter cooling the residue in an ice water bath
additionsaturated aqueous sodium bicarbonate is added
customthe precipitate collected
washrinsed with water
customdried

출처 및 근거

ORD 기록: ord-c4e1a6c1250a445185e50851c001f832
출처 데이터셋: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06211365B1

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