Thionyl Chloride → 1-(2-Chloroethoxy)-4-nitrobenzene

HRID 322630

반응식

HRID 322630 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12]O)=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)([Cl:16])=O>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][Cl:16])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 853812-(4-Nitrophenoxy)ethanol

생성물 1

HCID 27645871-(2-Chloroethoxy)-4-nitrobenzene

실험 절차

4-Nitro-(2-Hydroxyethoxy)benzene (1.13 g, 6.2 mmol) in thionyl chloride (10 mL) is heated at reflux for 3 hours then concentrated in vacuo. After cooling the residue in an ice water bath, saturated aqueous sodium bicarbonate is added and the precipitate collected, rinsed with water, and dried to give 4-nitro-(2-chloroethoxy)benzene (909 mg).

후처리

  1. temperatureat reflux for 3 hours
  2. concentrationthen concentrated in vacuo
  3. temperatureAfter cooling the residue in an ice water bath
  4. additionsaturated aqueous sodium bicarbonate is added
  5. customthe precipitate collected
  6. washrinsed with water
  7. customdried

출처 및 근거

ORD 기록
ord-c4e1a6c1250a445185e50851c001f832
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211365B1

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