Sodium Hydroxide → HCID 10644171, 화합물

HRID 322849노트

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HRID 322849 반응식
[CH2:1]([O:8][C:9]1[CH:22]=[C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:20]=[CH:19][C:10]=1[C:11]([NH:13][CH2:14][C:15]([O:17]C)=[O:16])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH2:1]([O:8][C:9]1[CH:22]=[C:21]([O:23][CH2:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:20]=[CH:19][C:10]=1[C:11]([NH:13][CH2:14][C:15]([OH:17])=[O:16])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10787454HCID 10787454, 화합물

생성물 1

HCID 10644171HCID 10644171, 화합물수율 34.5%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

A solution of methyl N-(2,4-dibenzyloxybenzoyl)glycinate (900 mg) in methanol (20 mL) is treated with 1 M NaOH (20 mL) and stirred at 25° C. for 2 hours. The solution is evaporated, the residue diluted with water, brought to pH 1 and extracted with ethyl acetate. The extract is dried and evaporated. The residue is recrystallized from methanol to yield N-(2,4-dibenzyloxybenzoyl)glycine as a colourless solid (300 mg), m.p. 183° C. H NMR (CDCl3) 4.15(2H,d), 5.05 (2H,s), 5.2(2H,s), 6.6(1H,s), 6.7(1H,d), 7.3-7.5(10H,m), 8.2(1H,d), 8.4(1H,t).

후처리

  1. customThe solution is evaporated
  2. additionthe residue diluted with water
  3. extractionextracted with ethyl acetate
  4. customThe extract is dried
  5. customevaporated
  6. customThe residue is recrystallized from methanol

출처 및 근거

ORD 기록
ord-27d4c5d9c7774501a70696183c432364
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211234B1

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