Methyl cyanoacetate → methyl (E)-3-(2,4-dibenzyloxyphenyl)-2-cyanoacrylate

HRID 322934

반응식

HRID 322934 반응식
[CH2:1]([O:8][C:9]1[CH:16]=[C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:14]=[CH:13][C:10]=1[CH:11]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]([CH2:27][C:28]([O:30][CH3:31])=[O:29])#[N:26].N1CCCCC1>C(O)C>[CH2:1]([O:8][C:9]1[CH:16]=[C:15]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:14]=[CH:13][C:10]=1/[CH:11]=[C:27](\[C:25]#[N:26])/[C:28]([O:30][CH3:31])=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7747Methyl cyanoacetateHCID 8082PiperidineHCID 18090802,4-Bis(benzyloxy)benzaldehyde

생성물 1

HCID 86756581methyl (E)-3-(2,4-dibenzyloxyphenyl)-2-cyanoacrylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2,4-dibenzyloxybenzaldehyde (1 g), methyl cyanoacetate (0.27 mL), piperidine (0.1 mL) and ethanol (30 mL) is stirred at ambient temperature for 20 minutes and the solvent is removed under reduced pressure. The residue is recrystallized from ethanol to give methyl (E)-3-(2,4-dibenzyloxyphenyl)-2-cyanoacrylate as a yellow solid (400 mg).

후처리

  1. customthe solvent is removed under reduced pressure
  2. customThe residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-c5088d268910443a81fef21ea2bc3c30
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211234B1

연결된 노트

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