Triethylamine → 3-Iodo-N-methoxy-N-methylbenzamide

HRID 322962

반응식

HRID 322962 반응식
[CH3:1][O:2]CN.C([N:7]([CH2:10]C)CC)C.[I:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[C:16](Cl)=[O:17]>ClCCl>[CH3:1][O:2][N:7]([CH3:10])[C:16](=[O:17])[C:15]1[CH:19]=[CH:20][CH:21]=[C:13]([I:12])[CH:14]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 743783-Iodobenzoyl chlorideHCID 177781771-Methoxymethanamine

생성물 1

HCID 223220523-Iodo-N-methoxy-N-methylbenzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A stirred solution of N-methoxymethylamine (3.47 g) and triethylamine (10.4 mL) in dichloromethane (100 mL) at 5° C. is treated dropwise with 3-iodobenzoyl chloride (9.8 g). The reaction mixture is stirred at room temperature for 2 hours, washed twice with water (70 mL), dried over magnesium sulphate, and evaporated to give N-methoxy-N-methyl-3-iodobenzamide (9.8 g) as a brown oil.

후처리

  1. washwashed twice with water (70 mL)
  2. dry with materialdried over magnesium sulphate
  3. customevaporated

출처 및 근거

ORD 기록
ord-e480a71bec5f485ab375837bfa47cb72
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211234B1

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