Furfural → 2-[2-(2-Furyl)ethenyl]-8-quinolinol

HRID 323005

반응식

HRID 323005 반응식
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[O:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[CH:18]=O>CC(C)=O>[O:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[CH:18]=[CH:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([OH:1])[CH:3]=[CH:4][CH:5]=2)[N:10]=1

참가 물질

4

반응물 2

HCID 7362FurfuralHCID 132242-Methyl-8-hydroxyquinoline

생성물 1

HCID 545715062-[2-(2-Furyl)ethenyl]-8-quinolinol

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 8-hydroxyquinaldine (5.09 g) and 2-furaldehyde (8.0 mL) are heated at reflux overnight. The reaction is cooled to room temperature. The residue is taken up in acetone and adsorbed onto silica. A silica gel column eluting with 100% CH2Cl2 is run and the product-containing fractions evaporated under reduced pressure to give an orange/yellow oil. The product is crystallized with EtOH/H2O, filtered, washed thoroughly with water, and dried (1.18 g).

후처리

  1. temperatureare heated
  2. temperatureat reflux overnight
  3. washA silica gel column eluting with 100% CH2Cl2
  4. customthe product-containing fractions evaporated under reduced pressure
  5. customto give an orange/yellow oil
  6. customThe product is crystallized with EtOH/H2O
  7. filtrationfiltered
  8. washwashed thoroughly with water
  9. customdried (1.18 g)

출처 및 근거

ORD 기록
ord-8d25002f24364c09889727a74d4f2bb0
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211376B1

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