Dichloromethane → (1-(4-Oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine Hydriodic Acid Salt

HRID 323346

반응식

HRID 323346 반응식
[O:1]=[C:2]([CH3:29])[CH2:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[NH:15][CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1.ClCCl.[IH:33]>O>[IH:33].[O:1]=[C:2]([CH3:29])[CH2:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[NH:15][CH:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 24841Hydrogen iodideHCID 22009233(1-(4-oxopentyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine

생성물 1

HCID 86756597(1-(4-Oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine Hydriodic Acid Salt

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Combine (1-(4-oxopentyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine, ethylene ketal (0.9 g, 2.0 mmol) and dichloromethane (20 mL). Cool in an ice bath and add hydriodic acid (0.53 mL, 57%, 4.05 mmol). Warm to ambient temperature. After 0.5 hours, add water (0.5 mL) and heat to reflux. After 18 hours, cool to ambient temperature and evaporate in vacuo to give the title compound.

후처리

  1. temperatureCool in an ice bath
  2. temperatureheat to reflux
  3. waitAfter 18 hours
  4. temperaturecool to ambient temperature
  5. customevaporate in vacuo

출처 및 근거

ORD 기록
ord-70c33d0dc40746d3859726d21fe62f3e
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211199B1

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