Methanol → 5-Acetyl-2-amino-4-methylthiazole
반응식
[NH2:1][C:2]([NH2:4])=[S:3].N1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C[OH:12]>>[NH2:1][C:2]1[S:3][C:8]([C:9](=[O:12])[CH3:10])=[C:7]([CH3:6])[N:4]=1참가 물질
4
실험 절차
A mixture of thiourea (5.18 g, 0.068 mol) in dry MeOH (20 mL) was stirred and cooled on an ice bath. Pyridine (2 mL) was added, followed by 3-chloro-2,4-pentadione (9.15 g, 0.068 mol) dropwise. After completion of the addition the reaction mixture was allowed to warm to r. t. and stirring was continued for 4 h. The precipitates were filtered and washed with EtOAc to afford white solid 1-(2-amino-4-methyl-thiazol-5-yl)-ethanone.
후처리
- temperaturecooled on an ice bath
- additionAfter completion of the addition the reaction mixture
- temperatureto warm to r
- stirringand stirring
- filtrationThe precipitates were filtered
- washwashed with EtOAc
출처 및 근거
- ORD 기록
- ord-8ed35d7d604744cb9c35b2475921893f
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07427627B2
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