Hydrochloric Acid → Racivir

HRID 323908노트

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HRID 323908 반응식
[CH2:1]1[S:5][C@H:4]([CH2:6][OH:7])[O:3][C@@H:2]1[N:8]1[C:13](=[O:14])[N:12]=[C:11]([NH2:15])[C:10]([F:16])=[CH:9]1.Cl>CO.O1CCOCC1>[NH2:15][C:11]1[C:10]([F:16])=[CH:9][N:8]([CH:2]2[O:3][CH:4]([CH2:6][OH:7])[S:5][CH2:1]2)[C:13](=[O:14])[N:12]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 60877Emtricitabine

생성물 1

HCID 9837769Racivir

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

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온도
0 °C

실험 절차

A mixture of (−)-FTC [32(2R, β/α)](60:40 of a β:α anomer mixture, 3.0 g) was dissolved in methanol (30 ml), cooled to 0° C., and treated with a 4.0 M solution of HCl in 1,4-dioxane (3.3 ml [1.1x]). The solution was stirred for 20 minutes, and subsequently concentrated to dryness affording an off-white solid.

후처리

  1. concentrationsubsequently concentrated to dryness
  2. customaffording an off-white solid

출처 및 근거

ORD 기록
ord-27217238c5624324837a1077f9a5e528
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06215004B1

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