Phenol → N-(1,1-dimethyl-2-phenoxyethyl)acetamide

HRID 323981

반응식

HRID 323981 반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:8][C:9]1[O:10][CH2:11][C:12]([CH3:15])([CH3:14])[N:13]=1>C(OCC)(=O)C>[CH3:11][C:12]([NH:13][C:9](=[O:10])[CH3:8])([CH3:15])[CH2:14][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 996PhenolHCID 744964,5-Dihydro-2,4,4-trimethyloxazole

생성물 1

HCID 18349669N-(1,1-dimethyl-2-phenoxyethyl)acetamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
220 °C

실험 절차

A mixture of phenol (33.2 g) and 2,4,4-trimethyloxazoline (18.1 g) was heated in a stirred pressure vessel at 220° C. for 48 hours. The oil obtained on cooling was dissolved in ethyl acetate, washed with 5M sodium hydroxide solution, water, brine, then dried and evaporated to give an oil which was distilled under high vacuum to give N-(1,1-dimethyl-2-phenoxyethyl)acetamide, b.p. 115-122° C. at 0.67 mbar.

후처리

  1. customThe oil obtained
  2. temperatureon cooling
  3. washwashed with 5M sodium hydroxide solution, water, brine
  4. customdried
  5. customevaporated
  6. customto give an oil which
  7. distillationwas distilled under high vacuum

출처 및 근거

ORD 기록
ord-1749e9a681eb441b84dcb70966c475f7
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06215001B1

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