Thionyl Chloride → 3-(Morpholin-4-yl)propane-1-sulfonyl chloride hydrochloride
반응식
S(Cl)([Cl:3])=O.[N:5]1([CH2:11][CH2:12][CH2:13][S:14]([OH:17])(=O)=[O:15])[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1>CN(C)C=O>[ClH:3].[N:5]1([CH2:11][CH2:12][CH2:13][S:14]([Cl:3])(=[O:17])=[O:15])[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1참가 물질
4
실험 절차
Thionyl chloride (10 ml) was added to 4-morpholinepropane sulfonic acid (4.4 g) followed by dimethylformamide (0.2 ml). The mixture was heated at reflux under nitrogen for 5 h. The thionyl chloride was removed in vacuo and the residue triturated with acetonitrile and filtered to give a white solid. This was dried at 80° C. in vacuo to give the title compound as a white solid (2.7 g). Found: C,31.9; H,5.9; N,5.1. C7H14CINO3S.HCl requires C,31.8; H,5.7; N,5.3%.
후처리
- temperatureThe mixture was heated
- temperatureat reflux under nitrogen for 5 h
- customThe thionyl chloride was removed in vacuo
- customthe residue triturated with acetonitrile
- filtrationfiltered
- customto give a white solid
- customThis was dried at 80° C. in vacuo
출처 및 근거
- ORD 기록
- ord-92545e80488c437e82342ec16f9d052a
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06215002B1
반응 노트
불러오는 중…