Water → 6-Bromo-3,4-dimethoxybenzaldehyde

HRID 324032

반응식

HRID 324032 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=[O:7].[Br:13]Br.O>C(O)(=O)C>[Br:13][C:8]1[C:5]([CH:6]=[O:7])=[CH:4][C:3]([O:2][CH3:1])=[C:10]([O:11][CH3:12])[CH:9]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 8419VeratraldehydeHCID 24408Bromine2회

생성물 1

HCID 793516-Bromo-3,4-dimethoxybenzaldehyde

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3,4-Dimethoxybenzaldehyde (398.8 g) is dissolved in acetic acid (1.8 liter), and thereto is added dropwise bromine (136 ml) at room temperature over a period of four hours. The mixture is stirred overnight, and thereto is added dropwise slowly again bromine (60 ml), and the mixture is stirred overnight. The reaction solution is added to water (7 liters), and the precipitated crystals are collected by filtration, washed with water, and dissolved in chloroform (2 liters). The chloroform solution is washed, dried, concentrated, and the residue is crystallized from dilsopropyl ether to give 6-bromo-3,4-dimethoxybenzaldehyde (470 g) as a colorless crystal.

후처리

  1. stirringthe mixture is stirred overnight
  2. filtrationthe precipitated crystals are collected by filtration
  3. washwashed with water
  4. dissolutiondissolved in chloroform (2 liters)
  5. washThe chloroform solution is washed
  6. customdried
  7. concentrationconcentrated
  8. customthe residue is crystallized from dilsopropyl ether

출처 및 근거

ORD 기록
ord-30b6ab9d5b8e4dd88081c5aa9401b4e2
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06214996B1

연결된 노트

불러오는 중…