Ioxynic acid → 2,6-Diiodo-4-(8-phenyloctylcarbamoyl)phenol

HRID 324078

반응식

HRID 324078 반응식
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:12])[C:10]=1[OH:11])[C:5]([OH:7])=O.[C:13]1([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][NH2:27])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[I:12][C:9]1[CH:8]=[C:4]([C:5](=[O:7])[NH:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:3]=[C:2]([I:1])[C:10]=1[OH:11]

참가 물질

3

반응물 2

HCID 12065Ioxynic acidHCID 1455568-Phenyloctan-1-amine

생성물 1

HCID 222375592,6-Diiodo-4-(8-phenyloctylcarbamoyl)phenol

실험 절차

The title compound was prepared as a solid (0.718 g, 66%) from 3,5-diiodo-4-hydroxybenzoic acid using 8-phenyloctylamine and a procedure similar to step 2 of Example 93; 1H NMR (DMSO-d6) δ1.17-1.36 (m, 8H), 1.41-1.61 (m, 4H), 2.48-2.60 (m, 2H), 3.20 (dd, J=5.9, 8.8 Hz, 2H), 7.10-7.21 (m, 3H), 7.21-7.30 (m, 2H), 8.21 (s, 2H), 8.40 (t, J=4.4 Hz, 1H), 10.06 (s, 1H); mass spectrum [(+) ESI], m/z 578 (M +H)+.

출처 및 근거

ORD 기록
ord-f11b309d33c0464e85088f9906c90eb6
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06214877B1

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