Sodium borohydride → HCID 70110715, 화합물
반응식
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[C:17](=[O:18])[C:12]3[N:13]=[C:14]([CH3:16])[S:15][C:11]=3[CH:10]=[CH:9][C:8]=2[CH:19]=1>CO.ClCCl>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[CH:17]([OH:18])[C:12]3[N:13]=[C:14]([CH3:16])[S:15][C:11]=3[CH:10]=[CH:9][C:8]=2[CH:19]=1참가 물질
5
실험 절차
Sodium borohydride (0.3 g) was added portionwaise to a suspension of the product from step (ii) (1 g) in a mixture of methanol (40 ml) and dichloromethane (30 ml) at room temperature. After 1 hour the reaction mixture was partitioned between dichloromethane and brine. The organic phase was collected, dried (MgSO4) and evaporated under reduced pressure to leave a beige foam. Yield: 1 g. Used directly in the next step.
후처리
- customAfter 1 hour the reaction mixture was partitioned between dichloromethane and brine
- customThe organic phase was collected
- dry with materialdried (MgSO4)
- customevaporated under reduced pressure
- customto leave a beige foam
출처 및 근거
- ORD 기록
- ord-47e158777f3844e59057d015886848eb
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06218376B1
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