Water → HCID 85980352, 화합물
반응식
[C:1]1([C:7](=O)[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:19][OH:20].C([O-])(=O)C.[Na+].O>CCO>[C:1]1([C:7](=[N:19][OH:20])[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
To a solution of 1-phenyl-4-(pyridin-4-yl)butan-1-one (2.0 g, 8.7 mmol) in 20 mL of EtOH was added hydroxylamine hydrochloride (0.73 g, 10 mmol) and sodium acetate (1.4 g, 17 mmol). The reaction flask was heated at 80° C. for 4 h and was then cooled to room temperature. Addition of water and filtration of the resultant precipitate afforded 2.0 g (89%) of the title compound.
후처리
- temperaturewas then cooled to room temperature
출처 및 근거
- ORD 기록
- ord-48d2c45886ca45d1be1716d61216c655
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07427632B2
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