Water → 4-(Hydroxyimino)-4-phenylbutanoic acid

HRID 32458

반응식

HRID 32458 반응식
O=[C:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+].O>CCO>[N:15](=[C:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6])[OH:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 728713-Benzoylpropionic acidHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 2319364-(Hydroxyimino)-4-phenylbutanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of 4-oxo-4-phenylbutyric acid (1.0 g, 5.3 mmol) in 50 mL of EtOH was added hydroxylamine hydrochloride (742 mg, 11 mmol) and sodium acetate (1.8 g, 21 mmol). The reaction flask was heated at 80° C. for 4 h and was then cooled to room temperature. Addition of water and filtration of the resultant precipitate afforded, after recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound.

후처리

  1. temperaturewas then cooled to room temperature
  2. customafforded
  3. customafter recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound

출처 및 근거

ORD 기록
ord-68b393ec68034dac9628e5ad9b064591
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427632B2

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