p-Tolunitrile → 4-Methylbenzene-1-carboximidamide hydrochloride
반응식
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([C:7]#[N:8])=[CH:3][CH:2]=1.C[O-].[Na+].[Cl-:13].[NH4+:14]>CO>[ClH:13].[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([C:7]([NH2:14])=[NH:8])=[CH:3][CH:2]=1참가 물질
5
실험 절차
To a solution of p-tolunitrile (10.0 g) in methanol (85 mlb) was added sodium methoxide (0.46 g) and the reaction was stirred at room temperature for 5 days. Ammonium chloride (4.6 g) was added and the reaction was stirred overnight. The reaction was filtered and the filtrate concentrated to an oil. After the addition of ether the off-white precipitate was collected and dried to give the title compound (4.52 g). Electrospray MS m/z 135 [M+H]+.
후처리
- stirringthe reaction was stirred overnight
- filtrationThe reaction was filtered
- concentrationthe filtrate concentrated to an oil
- additionAfter the addition of ether the off-white precipitate
- customwas collected
- customdried
출처 및 근거
- ORD 기록
- ord-5aa06194480444fd8bcc6bf2fb801662
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06218538B1
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