Boron tribromide → 1,3-Benzenediol, 5-chloro-
반응식
B(Br)(Br)Br.[Cl:5][C:6]1[CH:11]=[C:10]([O:12]C)[CH:9]=[C:8]([O:14]C)[CH:7]=1>C(Cl)Cl>[Cl:5][C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[C:8]([OH:14])[CH:7]=1참가 물질
4
실험 절차
BBr3 (26 mL; 0.275 mmol) was added to a solution of chloro-3,5-dimethyoxybenzene (10 g; 30 mmol) in CH2Cl2 (100 mL) at −70° C. The cooling bath was removed and the solution was stirred at room temperature for 4 days. After re-cooling to −70° C., MeOH was added (150 mL). After evaporation of the solvent, toluene was added and removed in vacuo. Purification by kugelrohr distillation afforded 9 g (100%) of the sub-title compound.
후처리
- customThe cooling bath was removed
- temperatureAfter re-cooling to −70° C.
- additionMeOH was added (150 mL)
- customAfter evaporation of the solvent, toluene
- additionwas added
- customremoved in vacuo
- customPurification
- distillationby kugelrohr distillation
출처 및 근거
- ORD 기록
- ord-5c2301bc40c447f2a2c5833beed983cc
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06221898B1
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