Nitrous Acid → Methyl 4-fluoro-2-phenylbenzoate

HRID 325210노트

반응식

HRID 325210 반응식
N[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:3]=1.N([O-])=O.[Na+].N(O)=O.[H+].[B-](F)(F)(F)[F:27]>>[CH3:9][O:8][C:6](=[O:7])[C:5]1[CH:10]=[CH:11][C:2]([F:27])=[CH:3][C:4]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 4

HCID 24529Nitrous AcidHCID 28118Tetrafluoroboric acidHCID 154069885-Amino-biphenyl-2-carboxylic acid methyl esterHCID 23668193Sodium Nitrite

생성물 1

HCID 54170746Methyl 4-fluoro-2-phenylbenzoate

실험 절차

A solution of methyl 4-amino-2-phenylbenzoate (1.0 equivalent) in dilute aqueous HBF4 is treated with NaNO2 (1.1 equivalents) until an excess of nitrous acid persists. The mixture is extracted into ethyl acetate which is dried and evaporated. The title ester is purified by chromatography on silica gel.

후처리

  1. extractionThe mixture is extracted into ethyl acetate which
  2. customis dried
  3. customevaporated
  4. customThe title ester is purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-a59aa93faa34482abdedab2de5b795a3
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06221865B1

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