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2-Aminopyridine → 4-[(Pyridin-2-ylamino)carbonyl]-2-phenylbenzoyl methionine methyl ester

HRID 325232
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HRID 325232 반응식
[CH3:1][O:2][C:3](=[O:27])[C@H:4]([CH2:23][CH2:24][S:25][CH3:26])[NH:5][C:6](=[O:22])[C:7]1[CH:12]=[CH:11][C:10]([C:13](O)=[O:14])=[CH:9][C:8]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.ON1C(=O)C2C=CC=CC=2N=N1.[NH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=1.Cl.CN(C)CCCN=C=NCC>CN(C=O)C.C(OCC)(=O)C>[CH3:1][O:2][C:3](=[O:27])[C@H:4]([CH2:23][CH2:24][S:25][CH3:26])[NH:5][C:6](=[O:22])[C:7]1[CH:12]=[CH:11][C:10]([C:13]([NH:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][N:42]=2)=[O:14])=[CH:9][C:8]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1
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참가 물질

7

반응물 4

HCID 104392-AminopyridineHCID 730263-hydroxy-1,2,3-benzotriazin-4(3H)-oneHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 206228254-Carboxy-2-phenylbenzoyl methionine methyl ester

생성물 1

HCID 206228404-[(Pyridin-2-ylamino)carbonyl]-2-phenylbenzoyl methionine methyl ester

시약·촉매·용매 2

HCID 6228Dimethylformamide용매
HCID 8857Ethyl Acetate용매

실험 절차

To a solution of the resultant acid from Example 60A (1.0 equivalent) in DMF is added 3-hydroxy-1,2,3-benzotriazin-4(3H)-one (1.5 equivalents) followed by 2-aminopyridine (1.0 equivalent) and 1-(3-dimehtylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.5 equivalents). When judged complete by TLC analysis, the reaction is taken up in ethyl acetate which is washed by 1N HCl and saturated brine, and then is dried and evaporated. The crude reaction mixture is purified by column chromatography to afford the title product.

후처리

  1. washis washed by 1N HCl and saturated brine
  2. customis dried
  3. customevaporated
  4. customThe crude reaction mixture
  5. customis purified by column chromatography

출처 및 근거

ORD 기록
ord-c0d1e95e86d74f5d9e0420a07cd6d5c2
출처 데이터셋
uspto-grants-2001_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06221865B1

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